AbstractResonance ionization spectroscopy is a newly developed technology enabling the counting of single atoms of materials. It is uniquely suited for use as an analytical tool for ultrasensitive elemental analysis. The method is described; typical data illustrating the principal features of the method are shown, and the formation of a spin-off company during the early stages of the U.S. government’s new initiative encouraging technology transfer is described. Alvin M. Weinberg’s contributions to the formation of this enterprise have been significant.