SummaryA general discussion is given of the significance of fibrinolysis as a hemorrhagic syndrome observed in patients with shock, cancer, premature separation of the placenta, etc. The factor of anoxemia appears to be determining in the appearance of fibrinolysis.Production of fibrinolysis in patients with thrombotic and embolic diseases represents a new thrombolytic therapy. It should be based on a correct understanding of the enzyme system and proper use of laboratory determinations.