The establishment of a permanent lunar base will employ separation processes that may be conducive to column operation. Reclamation of precious bodily fluids and products from chemical manufacture will be a part of routine necessity. The lunar environment, with reduced gravity and pressure, will offer some intriguing possibilities for operation such as vacuum distillation. The area for plate and packed columns will need to be increased in order to compensate for the reduction of gravitational forces responsible for moving the fluids. Plate efficiencies, hence column height, can increase or decrease, depending on the choice of scaling criteria applied to the plate geometry. Packed column height remains almost independent of gravity.