Event‐related fMRI of painentering a new era in imaging pain
作者:
Karen Davis,
Chun Kwan,
Adrian Crawley,
David Mikulis,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 13
页码: 3019-3023
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cingulate;Cortex;fMRI;Hemodynamic response;Insula;Pain;S2;Thalamus
数据来源: OVID
摘要:
PREVIOUS imaging studies of pain used a block design of prolonged (up to 1 min) noxious stimulation that are not well tolerated and subject to temporal interactions. We describe an adaptation of event-related fMRI to study pain with short duration stimuli. Functional images were acquired with a spiral sequence on a 1.5T GE echospeed MRI system of the thalamus, anterior cingulate, insula and second somatosensory cortex during brief (1–3 s) noxious thermal stimulation of the hand of normal volunteers. An MRI-compatible computerized rating system continuously monitored subjects' pain. Brief pain-related activations were clearly identified in the cortex and thalamus with a hemodynamic delay of 3–6 s. These findings demonstrate that brief stimuli combined with on-line pain ratings can be used to study pain with fMRI.
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