No Evidence of Linkage for Cleft Lip with or without Cleft Palate to a Marker Near the Transforming Growth Factor Alpha Locus in Two Populations
作者:
Diego F. Wyszynski,
Nancy Maestri,
Amy F. Lewanda,
Iain McIntosh,
Anne Smith,
Constanza García-Delgado,
Enrique Vinageras-Guarneros,
Eric Wulfsberg,
Terri H. Beaty,
期刊:
Human Heredity
(Karger Available online 1997)
卷期:
Volume 47,
issue 2
页码: 101-109
ISSN:0001-5652
年代: 1997
DOI:10.1159/000154397
出版商: S. Karger AG
关键词: Linkage;Birth defects;Polymerase chain reaction;Malformations
数据来源: Karger
摘要:
Nonsyndromic cleft lip with or without cleft palate is a common birth defect, affecting approximately 1 in 1,000 Caucasian newborns. Thirty-five multiplex families from the mid-Atlantic region of the United States and 22 families from central Mexico with a nonsyndromic form of cleft lip with or without cleft palate were selected for a linkage analysis. A tetranucleotide repeat marker (D2S443) located on the same yeast artificial chromosome as the transforming growth factor alpha locus was tested for linkage to a putative susceptibility Mendelian locus under varying levels of pentrance. No evidence for linkage between D2S443 and a susceptibility locus for cleft lip with or without cleft palate was found. Insight is given to explain this outcome in spite of the statistically significant associations found by other investigators.
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