Local Cerebral Glucose Utilization Is Increased in Acutely Adrenalectomized Rats
作者:
Massako Kadekaro,
Masanori Ito,
Paul M. Gross,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 47,
issue 4
页码: 329-334
ISSN:0028-3835
年代: 1988
DOI:10.1159/000124933
出版商: S. Karger AG
关键词: Corticotropin-releasing factor;Vasopressin;Adrenocorticotropic hormone;2-Deoxyglucose method;Paraventricular nuclei;Pituitary anterior lobe
数据来源: Karger
摘要:
The quantitative autoradiographic deoxyglucose method was used to study the effects of acute adrenalectomy on local cerebral glucose utilization in conscious albino rats. Five hours following removal of the adrenal glands, glucose utilization was increased (4–55%) throughout the brain, particularly in the locus ceruleus, hypothalamic paraventricular nucleus, hippocampus, median eminence and anterior lobe of the pituitary gland. These structures are involved in the regulation of corticotropin-releasing factor, vasopressin, and adrenocorticotropic hormone. Treatment with dexametha-sone (0.25 mg/kg i.m.) substantially reduced or prevented the stimulatory effects of adrenalectomy on cerebral glucose metabolism. These results demonstrate: (1) the existence of a negative feedback loop between the brain and adrenal glands in which corticosteroids exert an inhibitory action on glucose utilization of brain regions participating in adrenotropic regulation, and (2) a general inhibitory action of glucocorticoids on cerebral metabolis
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