Phenotypic variation in hereditary adenomatosisUnusual tumor spectrum
作者:
Henry Lynch,
Thomas Ruma,
William Albano,
Jane Lynch,
Patrick Lynch,
期刊:
Diseases of the Colon & Rectum
(OVID Available online 1982)
卷期:
Volume 25,
issue 3
页码: 235-238
ISSN:0012-3706
年代: 1982
出版商: OVID
关键词: Adenomatous polyposis coli, familial;Phenotype;Cancer, gastroesophageal;Colon;Rhabdomyosarcoma, pararectal
数据来源: OVID
摘要:
&NA;Familial adenomatous polyposis coli is a heterogeneous disease with respect to genetics as well as its colonic polyposis and cancer phenotype. The authors report a family with variation in phenotypic expression of polyps ranging from isolated polyps to florid carpeting of the entire colonic mucosal surface. In addition to early‐onset colonic cancer, a patient with isolated polyps had a seminoma and subsequently developed gastroesophageal cancer. His son, also with isolated colonic polyps, manifested a pararectal rhabdomyosarcoma. The significance of these variations can only be assessed fully through the study of cancer of all anatomic sites in many additional families.
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