Alterations in Influenza A Virus Specific Immune Injury in Mice Anesthetized with Halothane or Ketamine
作者:
A.M. Penna,
K.J. Johnson,
J. Camilleri,
P.R. Knight,
期刊:
Intervirology
(Karger Available online 1990)
卷期:
Volume 31,
issue 2-4
页码: 188-196
ISSN:0300-5526
年代: 1990
DOI:10.1159/000150153
出版商: S. Karger AG
关键词: Influenza A virus;Immunopathology;Neutrophils;Monocytes;Anesthetics;Halothane;Ketamine
数据来源: Karger
摘要:
CD-1 mice infected with a sublethal dose of influenza A virus were anesthetized for 2 h with halothane. These mice were compared to a control group which was similarly infected using ketamine sedation. Mice anesthetized with halothane showed less physical signs of illness and demonstrated less lung histopathology than the control group of mice. Virus titers were reduced in the group of animals exposed to halothane 12 h after infection, but were the same as the infected controls at all other times measured (1–12 days after infection). Morphometric analysis of lung tissue demonstrated a delayed appearance of both neutrophils and monocytes in the halothane-exposed mice. These results suggest that the halogenated volatile anesthetic halothane decreases the pulmonary pathogenesis of influenza A virus by altering the recruitment of immunological effector cells during the course of the infectio
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