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Functional promoter polymorphism of the human serotonin transporterlack of association with panic disorder

 

作者: J. Deckert,   M. Catalano,   A. Heils,   D. Bella,   F. Friess,   E. Politi,   P. Franke,   M. Nöthen,   W. Maier,   L. Bellodi,   K. Lesch,  

 

期刊: Psychiatric Genetics  （OVID Available online 1997）
卷期: Volume 7, issue 1  

页码: 45-48

 

ISSN:0955-8829

 

年代: 1997

 

出版商: OVID

 

关键词: Panic disorder;Promoter variant;Serotonin transporter

 

数据来源: OVID

 

摘要:

To probe the hypothesis of a role for a functionally relevant 44 hp insertion/deletion of the serotonin transporter promoter in the aetiopathogenesis of panic disorder, we determined the allele frequency of the variant in two samples (combinedn= 158) of panic disorder patients (DSMIII-R) and compared it with its allele frequency in two ethnically matched control samples (combinedn= 169). The fact that no difference could be observed (χ2analysis) argues against a major role for this serotonin transporter promoter polymorphism in the aetiopathogenesis of panic disorder.

 

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