Intestinal transplantation might become the alternative to definitive parenteral nutrition in patients with permanent intestinal failure. Indeed, recent advances in immunosuppressive treatment and better monitoring and control of acute rejection have brought intestinal transplantation into the realms of standard treatment of intestinal failure. This procedure may be performed in adult or paediatric patients under certain conditions. This short review focuses on the current clinical results and indications for intestinal transplantation and discusses the strategy regarding this challenging procedure.