Prognostic significance of serum bile acids in cirrhosis
作者:
Gerd A. Mannes, M.D.,
Christian Thieme,
Frans Stellaard,
Tiancai Wang,
Tilman Sauerbruch,
Gustav Paumgartner,
期刊:
Hepatology
(WILEY Available online 1986)
卷期:
Volume 6,
issue 1
页码: 50-53
ISSN:0270-9139
年代: 1986
DOI:10.1002/hep.1840060110
出版商: W.B. Saunders
数据来源: WILEY
摘要:
AbstractThe value of serum bile acid concentrations for predicting prognosis in cirrhotics was compared with the prognostic significance of clinical and laboratory findings in a prospective 1‐year study of 76 patients with cirrhosis. A commercial radioimmunoassay for total serum‐conjugated primary bile acids was used. Of 76 patients, 16 died within the follow‐up period. The concentration of bile acids in serum more closely correlated with mortality in cirrhosis than the commonly used clinical and laboratory parameters such as the Number Connection Test, ascites, albumin, pseudocholinesterase, bilirubin, prothrombin time and nutritional state. Serum bile acids alone yielded a prediction of mortality comparable to the Child classification. When logistic regression analysis was performed, optimal prediction of prognosis was achieved with the combination of serum bile acids and the Number Connection Test. Serum bile acid levels alone or in combination with the Number Connection Test may be a clinically useful prognostic index in cirr
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