Neonatal Treatment with Monosodium Glutamate Increases Plasma Corticosterone in the Rat
作者:
Miriam Sterman Dolnikoff,
Claudio Elias Kater,
Mizue Egami,
Iracema Senna de Andrade,
Maria Regina Marmo,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 48,
issue 6
页码: 645-649
ISSN:0028-3835
年代: 1988
DOI:10.1159/000125076
出版商: S. Karger AG
关键词: Monosodium glutamate;Corticosterone;Adrenal hyperfunction
数据来源: Karger
摘要:
Monosodium glutamate (MSG) has been shown to alter several neuroendocrine functions in neonatally treated rats. To evaluate for possible alterations in the hypothalamic-pituitary-adrenal axis, we injected rats during the neonatal period with MSG or saline (controls). An increase in basal plasma corticosterone levels associated with a blunted circadian variation was observed. Ether exposure produced a significant elevation in plasma corticosterone concentration in both groups of animals. However, while the increase in controls was 181.3% for male and 193.9% for female rats, in the MSG-treated rats it was only 60.7 and 31.6%, respectively. The intraperitoneal administration of high dexamethasone doses blocked corticosterone secretion in both groups. However, whereas the lowest dose (0.10 µg/kg) suppressed corticosterone secretion in control animals, it was ineffective in MSG-treated rats. The morphological study of adrenals revealed signs of a hyperfunctional state in MSG-treated rats. These data suggest that the central lesions produced by MSG treatment disrupt the regulation of the hypothalamic-pituitary-adrenal axis
点击下载:
PDF
(926KB)
返 回