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Antagonists of Trophic Hormones

 

作者: Josephine Milner,  

 

期刊: Gynecologic and Obstetric Investigation  (Karger Available online 1971)
卷期: Volume 2, issue 1-6  

页码: 65-72

 

ISSN:0378-7346

 

年代: 1971

 

DOI:10.1159/000301852

 

出版商: S. Karger AG

 

关键词: Trophic hormones;ACTH;adrenal;differentiation;cyclic AMP;antibiotics;mitochondria

 

数据来源: Karger

 

摘要:

Antagonists of pituitary trophic hormones may act either by inhibiting the synthesis and release of the hormone, by interfering with the interaction of the trophic hormone with its target tissue, or by inhibiting the intracellular response of the target cell. Taking the adrenocorticotrophin (ACTH) – adrenal cortical cell system some inhibitors of the “trophic” and “acute steroidogenic” responses of the cortical cells to ACTH are described. Finally the problems associated with using inhibitors of specific intracellular functions in the whole animal are considered.

 

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