Antagonists of Trophic Hormones
作者:
Josephine Milner,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1971)
卷期:
Volume 2,
issue 1-6
页码: 65-72
ISSN:0378-7346
年代: 1971
DOI:10.1159/000301852
出版商: S. Karger AG
关键词: Trophic hormones;ACTH;adrenal;differentiation;cyclic AMP;antibiotics;mitochondria
数据来源: Karger
摘要:
Antagonists of pituitary trophic hormones may act either by inhibiting the synthesis and release of the hormone, by interfering with the interaction of the trophic hormone with its target tissue, or by inhibiting the intracellular response of the target cell. Taking the adrenocorticotrophin (ACTH) – adrenal cortical cell system some inhibitors of the “trophic” and “acute steroidogenic” responses of the cortical cells to ACTH are described. Finally the problems associated with using inhibitors of specific intracellular functions in the whole animal are considered.
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