Immunocytochemical Localization of Insulin-Like Growth Factor I in the Hypothalamo-Hypophyseal System of the Adult Rat
作者:
Fernando Aguado,
Teresa Fernández,
Ricardo Martínez-Murillo,
José Rodrigo,
Lucinda Cacicedo,
Franco Sánchez-Franco,
期刊:
Neuroendocrinology
(Karger Available online 1992)
卷期:
Volume 56,
issue 6
页码: 856-863
ISSN:0028-3835
年代: 1992
DOI:10.1159/000126317
出版商: S. Karger AG
关键词: Insulin-like growth factor I;Hypothalamo-hypophyseal system;Immunocytochemistry
数据来源: Karger
摘要:
Insulin-like growth factor I (IGF-I) is shown to be involved in the regulation of pituitary hormones. High IGF-I concentrations were detected in hypothalamus and pituitary during adulthood. This study was undertaken to analyze the cellular distribution of IGF-I in the hypothalamo-hypophyseal system of the adult rat using immunocytochemical procedures. IGF-I was found to be widely distributed throughout the hypothalamus; it was present in the magnocellular neurons of the supraoptic, paraventricular, and accessory nuclei. Moreover, nerve fibres and puncta containing immunoreactive IGF-I were localized in the median eminence and the posterior lobe of the pituitary. These results support possible IGF-I neuromodulatory or neurohormonal action in the hypothalamus on pituitary hormone regulation.
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