Statistical Power of an Exact Test of Hardy-Weinberg Proportions of Genotypic Data at a Multiallelic Locus
作者:
Ranajit Chakraborty,
Yixi Zhong,
期刊:
Human Heredity
(Karger Available online 1994)
卷期:
Volume 44,
issue 1
页码: 1-9
ISSN:0001-5652
年代: 1994
DOI:10.1159/000154181
出版商: S. Karger AG
关键词: Permutation test;Monte Carlo;Type II error;Multiple alleles;Random mating
数据来源: Karger
摘要:
A computer algorithm for numerical evaluation of the statistical power of an exact test of Hardy-Weinberg genotypic proportions (HWP), developed here, indicates that the power is dependent on the number of segregating alleles as well as allele frequencies. While low levels of departure from the null hypothesis are difficult to detect from single-locus data, should such deviation be due to population substructuring, multiple loci, at each of which the number of segregating alleles is large (as seen with hypervariable loci), may easily detect even low levels of departure from HWP. Undetected small levels of departure may still provide conservative’ estimates of genotype frequencies from allele frequency data, following the current practice in forensic genetic
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