A comparative study was conducted to contrast the hepatotoxicity of several chemicals in the musk shrew(Suncus murinus) versusother common laboratory species (mouse or rat), and the following results were obtained from serum enzymes (SCOT and SCPT) and histopathological findings of liver specimens. (1) The sensitivity ofSuncusliver toCC/4was different from that of mouse liver. (2) The sensitivity ofSuncusliver to β‐D‐galactosamine was weaker than that of rat liver. (3) The sensitivity ofSuncusliver to ethanol was stronger than that of mouse liver. Afterasingle oral administration of ethanol (99.5% vlv,0.7ml/50 g body weight), the gallbladder ofSuncusbecame enlarged and dark blue in color. (4) A striking fatty degeneration was seen 24 h after a single ip administration of amethopterin at 50 mg/kg inSuncusliver.