Biafine Applied on Human Epidermal Wounds Is Chemotactic for Macrophages and Increases the IL1/IL6 Ratio
作者:
Bernard Coulomb,
Laurence Friteau,
Louis Dubertret,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1997)
卷期:
Volume 10,
issue 5-6
页码: 281-287
ISSN:1660-5527
年代: 1997
DOI:10.1159/000211516
出版商: S. Karger AG
关键词: Human skin;Epidermal wound healing;Macrophage;Interleukin-1β;Interleukin-6
数据来源: Karger
摘要:
Using a model of pure epidermal wounds in normal human volunteers, we have studied the effects of Biafme® emulsion firstly on inflammatory cell migration, vascular permeability and cytokine release during the first 24 h, and secondly on epidermal wound healing by measuring transepidermal water loss from day 1 to day 7. Under these conditions, Biafme does not improve epidermal healing, in contrast to what is observed with bleeding dermoepidermal wounds. Our results suggest that the effects of Biafine are essentially at the dermis level. The analysis of epidermal wound exudates leads to the same conclusion. As a matter of fact, we demonstrated that Biafine is chemotactic for macrophages and increases the IL-l/IL-6 ratio, chiefly by reducing the secretion of IL-6. This study permits to progressively clarify the mode of action of Biafine, that seems to be located at the level of granulation tissue formation and not at the epidermal level
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