Optical resolution of two isomeric naphthylalanines by immobilized enyzmes
作者:
Martine Pugnière,
Bertrand Castro,
Aldo Previero,
期刊:
Chirality
(WILEY Available online 1991)
卷期:
Volume 3,
issue 3
页码: 170-173
ISSN:0899-0042
年代: 1991
DOI:10.1002/chir.530030305
出版商: Alan R. Liss, Inc.
关键词: β‐(1‐naphthyl)alanine;β‐(2‐naphthyl)alanine;alumina;α‐chymotrypsin;subtilisin
数据来源: WILEY
摘要:
AbstractOptical resolution of β‐(1‐naphthyl)alanine and β‐(2‐naphthyl)alanine have been efficiently carried out through enzymatic hydrolysis of their methyl ester and/orN‐acetyl ester derivatives by immobilized enzymes. Difficulties related to the lipophilic character of these amino acids were overcome by using emulsions ofn‐butyl acetate–water as reaction medium. The use of an automatic recirculating apparatus allowed reproducible and repetitive use of the immobiliz
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