Alcohol, Prolonged Isolation and Barbiturate Sedation in Two Strains of Mice
作者:
L. Valzelli,
S. Bernasconi,
期刊:
Neuropsychobiology
(Karger Available online 1978)
卷期:
Volume 4,
issue 2
页码: 86-92
ISSN:0302-282X
年代: 1978
DOI:10.1159/000117622
出版商: S. Karger AG
关键词: Ethanol;Pentobarbital;Prolonged socioenvironmental deprivation;Mice strains;Barbiturate sleeping time
数据来源: Karger
摘要:
Mice subjected to prolonged socioenvironmental deprivation gradually develop hyperirritability and hyperreactivity to physical stimuli. This heightened neuroexcitability may or may not debouch into aggressiveness according to strain and sex of the animals, and it is accompanied by a reduced sensitivity to CNS depressants. Socioenvironmental deprivation or isolation is shown to decrease the sensitivity either to pentobarbital or to ethanol potentiation of pentobarbital sleeping time in male mice from two different strains.
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