Restorative Neurosurgery: Opportunities for Restoration of Function in Acquired, Degenerative, and Idiopathic Neurological Diseases
作者:
Todd Thompson,
L. Lunsford,
Douglas Kondziolka,
期刊:
Neurosurgery
(OVID Available online 1999)
卷期:
Volume 45,
issue 4
页码: 741-741
ISSN:0148-396X
年代: 1999
出版商: OVID
关键词: Cell transplantation;Central nervous system;Functional neurosurgery;Gene therapy;Immunosuppression;Neurotrophic factors;Restorative neurosurgery;Stereotactic surgery
数据来源: OVID
摘要:
HISTORICALLY, NEUROSURGERY HAS improved the environment of the nervous system to promote maximal spontaneous recovery of function. The population of patients whom we treat at present is a small portion of those who suffer from disabling neurological illnesses. Based on a combination of new technology, and advances in neuroscience, restorative neurosurgery is advancing the frontiers of our specialty, and providing the potential to restore lost function. Significant advancements in gene therapy, the discovery and delivery of neurotrophic factors, and cell transplantation now require neurosurgeons to broaden the scope of our practice so that it includes the restoration of function in an enormous number of patients with acquired, degenerative and idiopathic neurological diseases. In order to meet the present challenge, neurosurgeons must broaden our vision, our role, and our future educational goals. In this review, we summarize the landmark advances in the basic and clinical neurosciences and the results of clinical trials that are driving our evolution from passive reaction to disease to active attempts to restore lost central nervous system function.
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