Weight Changes in Antidepressants: A Comparison of Amitriptyline and Trazodone
作者:
Hecht Orzack,
Jonathan O. Cole,
Loren Friedman,
Michael Bird,
John McEachern,
期刊:
Neuropsychobiology
(Karger Available online 1986)
卷期:
Volume 15,
issue 1
页码: 28-30
ISSN:0302-282X
年代: 1986
DOI:10.1159/000118283
出版商: S. Karger AG
关键词: Amitriptyline;Trazodone;Weight fluctuation;Side effects;Antidepressant effect
数据来源: Karger
摘要:
Weight data taken from a 6-week randomized double-blind study comparing amitriptyline, trazodone and placebo were analyzed to determine differential weight changes between the two drugs. In 272 depressed outpatients doses were increased over a period of 4 days to reach a maximum level of 200 mg amitriptyline or 400 mg trazodone. After grouping the subjects according to initial weights (ideal, overweight, 20% above, and underweight, 20% below) mean changes were determined for each treatment. The results indicate that amitriptyline, which differed from placebo and trazodone, produced significantly higher weight gains in the ideal and overweight groups. Trazodone on the other hand produced a slight weight loss in the overweight group. Due to a low number of patients in the underweight group, the results were not significant statistically. The antidepressant effects of both trazodone and amitriptyline were the same and no correlations between Hamilton scores and weight change were found.
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