Content, Synthesis, and Function of Polyamines in Trypanosomatids: Relationship to Chemotherapy1,2
作者:
CYRUS J. BACCHI,
期刊:
The Journal of Protozoology
(WILEY Available online 1981)
卷期:
Volume 28,
issue 1
页码: 20-27
ISSN:0022-3921
年代: 1981
DOI:10.1111/j.1550-7408.1981.tb02798.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
ABSTRACTPolyamines are multiply amine‐substituted straight‐chain aliphatics; their content in different tissues may vary widely, and their functions are many. Their main routes of biosynthesis originate from ornithine and methionine. Polyamine content and biosynthesis in tryposomatid flagellates are reviewed concluding with emphasis on their possible role as critical drug targets in these parasitic protozoa so pathogenic for man in large areas of the wo
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