Luikov approach was applied to predict drying time and temperature of a droplet containing liquid substrate of entobacterin in the falling drying rate period. Analytical expressions describing both average and local temperatures of the particle in the drying process were derived and solved. Constants necessary to solve the equations, describing certain material properties and material moisture bonding were found in simple experiments. An experimental relationship of Rebinder number and moisture content of the material enabled to calculate changes of average droplet temperature in the falling drying rate period. Analytical solutions of heat transfer equations for shrinkage core model both for a linear and exponential change of moisture content of the droplet in the drying process were delivered. Employing experimental heat transfer coefficient, drying time and droplct temperature field were determined. Comparison of experimental and predicted drying times as well as droplet temperatures shows small discrepancy. Results obtained can be used to predict quality of labile products in the course of drying.