Superoxide Scavenging by Thiol/Copper Complex of Captopril - An Epr Spectroscopy Study
作者:
ReguliJán,
MiŝíkVladimír,
期刊:
Free Radical Research
(Taylor Available online 1995)
卷期:
Volume 22,
issue 2
页码: 123-130
ISSN:1071-5762
年代: 1995
DOI:10.3109/10715769509147534
出版商: Taylor&Francis
关键词: Superoxide radical;captopril;glutathione;thiol/copper complexes;SOD-mimics;EPR spin trapping
数据来源: Taylor
摘要:
Scavenging of superoxide radical by angiotensin converting enzyme (ACE) inhibitor captopril (CAP), a thiol compound, was studied by several investigators and the results were contradictory; while some reported a high superoxide scavenging activity of CAP others found that CAP removed superoxide inefficiently. In this work we show that in the presence of copper ions the apparent rate of superoxide removal by CAP (molar ratio CAP:CuSO4= 4:1) was two orders of magnitude higher (≈1.5×105M−1s−1at pH 7.4) than the literature value for superoxide scavenging by CAP alone (<10 M−1s−1at pH 7.4). We presume that in the presence of copper ions a CAP/copper complex with a SOD-mimicking activity is being formed. Similar results were also obtained with another thiol glutathione (GSH). The possible role of the CAP/copper complexes in the anti-inflammatory effect of CAP is discussed.
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