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Freeze-Drying of Pharmaceutical Crystalline and Amorphous Solutes in Vials: Dynamic Multi-Dimensional Models of the Primary and Secondary Drying Stages and Qualitative Features of the Moving Interface

 

作者: A. I. Liapis,   R. Bruttini,  

 

期刊: Drying Technology  (Taylor Available online 1995)
卷期: Volume 13, issue 1-2  

页码: 43-72

 

ISSN:0737-3937

 

年代: 1995

 

DOI:10.1080/07373939508916942

 

出版商: Taylor & Francis Group

 

关键词: Freeze-drylng of pharmaceuticals in vials;Lyophilization of pharmaceuticals in vials;Crystalline solutes;Amorphous solutes

 

数据来源: Taylor

 

摘要:

Dynamic and spatially multi-dimensional mathematical models of the primary and secondary drying stages of the freeze-drying of pharmaceutical crystalline and amorphous solutes in vials, are constructed and presented in this work. The models account for the removal of free and bound water and could also provide the geometric shape of the moving interface and its position. It is proved that the temperature of the moving interface can not be constant if the flux of heat flow to the sides of the vial is not zero. It is also proved that the slope of the free surface (moving interface) at the edge of the vial is always curved downward.

 

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