Immunolocalization of vgr (BMP‐6, DVR‐6), a TGF‐β related cytokine, to Schwann cells of the rat peripheral nervous system: Expression patterns are not modulated by autoimmune disease
作者:
Hermann J. Schluesener,
R. Meyermann,
S. Jung,
期刊:
Glia
(WILEY Available online 1995)
卷期:
Volume 13,
issue 1
页码: 75-78
ISSN:0894-1491
年代: 1995
DOI:10.1002/glia.440130109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Transforming growth factor;Peripheral nervous system;Bone morphogenetic protein;Neuritis
数据来源: WILEY
摘要:
AbstractThe transforming growth factors type β (TGF‐β) have been implicated in regulation of peripheral nervous system inflammation and regeneration. Here we demonstrate expression of a TGF‐β‐related bone morphogenetic protein, the vgr (BMP‐6, DVR‐6) in Schwann cells of the rat peripheral nervous system. The expression of vgr in the peripheral nervous system suggests that this factor and probably other TGF‐β‐related bone morphogenetic proteins might participate in Schwann cell function during aspects of peripheral nervous system physiology and pathology. However, we did not observe changes in expression patterns in response to autoimmune inflammation (experimental autoimmune neuritis) of the peripheral nervous system. © 19
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