Increased Expression of Lung Resistance-Related Protein and Multidrug Resistance-Associated Protein Messenger RNA in Childhood Acute Lymphoblastic Leukemia
作者:
Besim,
Ogretmen Julio,
Barredo Ahmad,
期刊:
Journal of Pediatric Hematology/Oncology
(OVID Available online 2000)
卷期:
Volume 22,
issue 1
页码: 45-49
ISSN:1077-4114
年代: 2000
出版商: OVID
关键词: LRP;MRP;MDR1;Childhood ALL;Multidrug resistance
数据来源: OVID
摘要:
Immunophenotype might be an important indicator for multidrug resistance (MDR) profiles in childhood acute lymphoblastic leukemia (ALL). The authors analyzed the messenger RNA (mRNA) levels of MDR1, multidrug resistance-associated protein (MRP), and lung resistance-related protein (LRP) by reverse transcriptase-polymerase chain reaction (RT-PCR) in childhood pre-B ALL, T-cell ALL, and acute nonlymphoblastic leukemia (ANLL). Results showed that MRP and LRP, but not MDR1, mRNAs are overexpressed, particularly in children with pre-B ALL compared with T-cell ALL and ANLL tested. In addition, the MRP and LRP mRNA expression levels in initial diagnosis and first relapse samples of one patient with pre-B ALL were similar. Consequently, these preliminary results suggest that the expression of these MDR-related genes in childhood ALL might be regulated differently in a lineage dependent manner.
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