Role of Glutathione Metabolism in the Reduction of Proteinuria by Dimethylthiourea in Adriamycin Nephrosis
作者:
Lawrence S. Milner,
Shu H. Wei,
Sidney J. Stohs,
Zuhair M. Eldeen,
Mark T. Houser,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 2
页码: 192-197
ISSN:1660-8151
年代: 1992
DOI:10.1159/000187032
出版商: S. Karger AG
关键词: Adriamycin nephrosis;Proteinuria;Dimethylthiourea;Glutathione;Free radicals
数据来源: Karger
摘要:
Glutathione (GSH) metabolism, a tissue detoxification pathway, was evaluated in rats with adriamycin nephrosis (AN) treated with dimethylthiourea (DMTU), a free radical scavenger. After 7 days of DMTU, a significant reduction in proteinuria occurred as compared to AN controls (62.4 ± 13.3 vs. 155.0 ± 24.0 mg/24 h). A significant increase in renal cortical GSH content as well as glutathione peroxidase (GP) and transferase (GT) activities occurred in DMTU-treated rats as compared to controls. Glutathione monoethyl ester (GME) administration alone reduced proteinuria by 21% in AN, which was not significant despite a large increase in the renal GSH content, however, GP and GT activities were not increased by GME. We conclude that DMTU ameliorates glomerular injury in AN by stimulating GSH metabolis
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