The alteration of actinomycin D teratogenicity by hormones and nucleic acids
作者:
J. Elis,
J. A. DiPaolo,
期刊:
Teratology
(WILEY Available online 1970)
卷期:
Volume 3,
issue 1
页码: 33-38
ISSN:0040-3709
年代: 1970
DOI:10.1002/tera.1420030108
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractActinomycin D (act D) was teratogenic to Syrian hamsters. The most effective dosage, 200 μg/kg of body weight, produced malformations when injected on day 4, 6, 8 or 10 of gestation. 100 μg/kg produced malformations only after injections on day 6 or 8. 300 μg/kg was strongly embryolethal, but some malformed fetuses were found among live survivors. 400 μg/kg caused 100% maternal lethality. The teratogenicity and fetal and maternal lethality were reduced when act D was mixed with nucleic acids. DNA was more potent than RNA in preventing toxic effects of act D. The embryolethal effect of act D was also diminished by treatment with a combination of 4 mg progesterone and 1 μg of estrone, although maternal lethality and teratogenicity were not preve
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