Toward a Rational Therapeutic Strategy for ArachnoiditisA Possible Role for d‐Penicillamine
作者:
R. GRAHAME,
B. CLARK,
M. WATSON,
C. POLKEY,
期刊:
Spine
(OVID Available online 1991)
卷期:
Volume 16,
issue 2
页码: 172-175
ISSN:0362-2436
年代: 1991
出版商: OVID
关键词: arachnoiditis;therapy;penicillamine
数据来源: OVID
摘要:
Twenty-six patients (13 men and 13 women), ranging in age from 38 to 75 years, with surgical andlor radiculographic evidence of chronic adhesive spinal arachnoiditis (CASA) were admitted to a randomly allocated, doubleblind, 6-month crossover trial of d-penicillamine (500 mglday) versus matching placebo. Assessments using subjective and objective criteria at 3-month intervals demonstrated no statistically significant effect with either d-penicillamine or placebo or between them. Thirteen of the 17 patients completing the trial expressed no clear preference. One patient preferred placebo. The remaining three patients who expressed strong preference for dpenicillamine (supported by objective data) subsequently maintained improvement on long-term therapy for up to 5 years. It is concluded that there may be a small subgroup of patients with CASA who might benefit from d-penicillamine therapy]
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