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The Inhibition of Platelet Prothrombinase Activity by Prostacyclin

 

作者: R.F.A. Zwaal,   P. Comfurius,   H.C. Hemker,   E.M. Bevers,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  （Karger Available online 1984）
卷期: Volume 14, issue 4  

页码: 320-324

 

ISSN:1424-8832

 

年代: 1984

 

DOI:10.1159/000215082

 

出版商: S. Karger AG

 

关键词: Platelets;Prostacyclin;Prothrombinase

 

数据来源: Karger

 

摘要:

Prostacyclin is able to inhibit the development of platelet prothrombinase activity. This inhibition, which also occurs with dibutyryl cAMP, is presumably due to the ability of prostacyclin to prevent the formation of a negatively charged phospholipid surface at the exterior half of the platelet membrane. Generation of this procoagulant surface, as induced by platelet activation with collagen plus thrombin, does not depend on thromboxane A2 formation.

 

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