Ouabain Pharmacokinetics in Dog and ManDetermination by Radioimmunoassay
作者:
Richard Selden,
Thomas Smith,
William Findley,
期刊:
Circulation
(OVID Available online 1972)
卷期:
Volume 45,
issue 6
页码: 1176-1182
ISSN:0009-7322
年代: 1972
出版商: OVID
关键词: Cardiac glycoside;Ouabain-specific antibody;Digitalis glycoside;Tritiated ouabain;G-Strophanthin
数据来源: OVID
摘要:
The pharmacokinetics of the relatively polar and rapidly acting cardiac glycoside ouabain (G-strophanthin) were studied in dogs and human subjects by the use of a newly devised radioimmunoassay technic. This method had high specificity and a sensitivity of less than 0.1 ng of ouabain per ml of plasma or urine. After administration of a single intravenous dose, the plasma ouabain concentration fell rapidly in both dogs and humans. After 7 hours, a phase of exponential decline was reached which had a half-life of 18 hours in dogs and 21 hours in normal human subjects. Repeated intravenous administration of ouabain to human subjects for 9 consecutive days resulted in the establishment of a plateau of plasma concentration and urinary excretion after 4-5 days, confirming plasma and urinary half-lives in the 19-24-hour range. The mean ratio of renal clearance of ouabain to that of creatinine was 0.81 in the human subjects. The plasma half-life of ouabain determined in these studies is in good agreement with previous observations of the half-life of dissipation of positive inotropy and of slowing of ventricular response to atrial fibrillation after ouabain administration.
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