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New abietane diterpenoids from the cones ofLarix kaempferi

 

作者: Hironori Ohtsu,   Reiko Tanaka,   Yasuko In,   Shunyo Matsunaga,   Harukuni Tokuda,   Hoyoku Nishino,  

 

期刊: Canadian Journal of Chemistry  (NRC Available online 2000)
卷期: Volume 78, issue 1  

页码: 31-40

 

ISSN:0008-4042

 

年代: 2000

 

DOI:10.1139/v99-218

 

出版商: NRC Research Press

 

数据来源: NRC

 

摘要:

A new podocarpane diterpene, 7&agr;,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7&agr;,13&bgr;,15,18-tetraol (2), 7&agr;,13&bgr;,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13&bgr;,18-dihydroxyabiet-8(14)-en-7-one (4), 13&bgr;,15,18-trihydroxyabiet-8(14)-en-7-one (5), 7-oxo-13&bgr;-methoxyabiet-8(14)- en-18-oic acid (7), abiet-8(14)-en-7&agr;,12&agr;,13&bgr;,18-tetraol (8), 7&agr;,12&agr;,13&bgr;-trihydroxyabiet-8(14)-en-18-oic acid (9), and abiet-8(14)-en-7&agr;,12&agr;,13&bgr;,15,18-pentaol (10) were isolated from the CHCl3extract of the cones ofLarix kaempferi. Their structures were determined on the basis of chemical and spectral evidence. The inhibitory effects of compounds1-4and7-9on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), were examined for a primary screening for anti-tumor promotors.Key words:Larix kaempferi, Pinaceae, cones, abietane, EBV-EA.

 

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