In Chronic Uremia, Insulin Activates Receptor Kinase but Not Pyruvate Dehydrogenase
作者:
Ivan Contreras,
José F. Caro,
Laura Aveledo,
Keybell Diaz,
Pedro Durrego,
José R. Weisinger,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 61,
issue 1
页码: 77-81
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186839
出版商: S. Karger AG
关键词: Insulin;Insulin receptor;Insulin resistance;Tyrosine kinase;Pyruvate dehydrogenase;Uremia;Experimental uremia
数据来源: Karger
摘要:
We studied in vivo biochemical effects of insulin in the skeletal muscle of chronically uremic and control rats. The rate of disappearance of blood glucose (determined with a short intravenous test) was reduced by 38% in uremia (p < 0.05). Intraperitoneal treatment with insulin plus glucose for 30 min caused a 3-fold increase in the activity of insulin receptor tyrosine kinase in the skeletal muscle of both rat groups. Conversely, pyruvate dehydrogenase activity increased by 115% in controls but only by 26% in uremics (p < 0.01). Exercise (swimming for 30 min) increased muscle pyruvate dehydrogenase activity approximately 2-fold in both groups of animals. These experiments show that in uremic rats, insulin binds normally to its muscle receptors and adequately activates receptor tyrosine kinase but fails to activate an otherwise responsive pyruvate dehydrogenase.
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