High-Dose Cytosine Arabinoside and Mitoxantrone (HAM) for the Treatment of Refractory Acute Lymphoblastic Leukemia
作者:
W. Hiddemann,
H. Kreutzmann,
R. Donhuijsen-Ant,
M. Planker,
F.-C. Wendt,
T. Büchner,
期刊:
Onkologie
(Karger Available online 1987)
卷期:
Volume 10,
issue 1
页码: 11-12
ISSN:0378-584X
年代: 1987
DOI:10.1159/000216359
出版商: S. Karger GmbH
关键词: Refractory ALL;Cytosine arabinoside;Mitoxantrone
数据来源: Karger
摘要:
In a clinical phase-II study 11 patients with refractory ALL were treated with high-dose AraC and mitoxantrone in combination (HAM). Refractoriness was defined as: 1. primary resistance against the BMFTinduction protocol; 2. first relapse with non-response to the B-ALL/NHL regimen as salvage treatment; 3. second and subsequent relapses. Therapy consisted of HD-AraC 3 g/m2 every 12 h by a 3-h infusion on days 1–4 and mitoxantrone 10 mg/m2/d on days 2–6. Seven of the 11 patients achieved a complete remission, 1 patient was refractory against 2 HAM cycles and 3 patients died during bone marrow aplasia. Toxicity was acceptable, consisting mainly of nausea and vomiting, mucositis and diarrhea. One patient who had completed the prophylactic CNS treatment with intrathecal MTX and cranial irradiation immediately before entering the HAM protocol developed severe signs of cerebral toxicity. These data indicate a significant activity of HAM in refractory ALL and suggest that the combination should be applied at earlier stages of ALL treatm
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