SERUM F PROTEIN ESTIMATION IN LIVER ALLOGRAFT RECIPIENTS WITH GRAFT DYSFUNCTION
作者:
GEOFFREY FORBES,
DAVID OLIVEIRA,
ROBIN HUGHES,
JOHN O'GRADY,
ROY CALNE,
ROGER WILLIAMS,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 6
页码: 995-997
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
Serum levels of F protein, a 44 kD cytoplasmic protein mainly found in hepatocytes, become elevated during episodes of graft dysfunction following orthotopic liver transplantation. In a study of 27 liver transplant recipients, the rise in F protein did not precede rises in the other conventional biochemical indices of hepatic dysfunction. Serum F protein concentration significantly correlated with serum levels of aspartate aminotransferase, gammaglutamyltransferase, alkaline phosphatase, and bilirubin (allP< 0.001) and also with the prothrombin time (P = 0.048). Despite its high concentration in liver cells, this marker does not provide any additional benefit in the diagnosis of graft dysfunction or in monitoring liver allograft function following transplantation.
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