Cross‐excitation in dorsal root ganglia does not depend on close cell‐to‐cell apposition
作者:
Vera Shinder,
Ron Amir,
Marshall Devor,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 18
页码: 3997-4000
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Close apposition;Crosstalk;Dorsal root ganglion;Pain;Satellite cell sheath
数据来源: OVID
摘要:
ABOUT 90% of neurons in dorsal root ganglia (DRGs) of rats 2–5 weeks of age are depolarized and excited by impulse activity in neighboring neurons that share the same DRG. Synaptic contacts are extremely rare in DRGs, but instances of close membrane apposition between pairs of neuronal somata are not uncommon, especially in prenatal rats. Close membrane apposition could permit electrotonic interactions among neighboring DRG neurons. We carried out an ultrastructural examination of DRGs taken from rats 2–5 weeks of age and found that by this age <2% of cells remain in close apposition with neighbors. The remainder are separated by one or two layers of satellite glial cytoplasm. It is, therefore, unlikely that close apposition between adjacent neurons contributes significantly to functional cross-excitation in the DRG.
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