ObjectiveTo investigate the concentrations of triglyceride, cholesterol, and high-density lipoprotein during a 50-hr infusion of 2% propofol, starting within 24 hrs of admission to the intensive care unit (ICU).DesignProspective, clinical study.SettingICU, university hospitalPatients2 days, were studied for 50 hrs, begining at 1800 hrs on the first day of ICU admission.Measurements and Main Results1000 pg/mL, but there was no relationship between concentrations of cytokines and triglycerides in plasma.ConclusionsInfusion of 2% propofol to critically ill patients over a 50-hr period does not result in a significant increase in triglyceride concentrations. Mean cholesterol and high-density lipoprotein concentrations were low throughout the study period. There was a significant direct correlation between triglyceride and C-reactive protein and an inverse correlation between cholesterol and C-reactive protein, suggesting that the changes in lipids in critically ill patients may be partly attributable to the acute-phase response. (Crit Care Med 1997; 25:1976-1981)