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Toxicity of ozone and nitrogen dioxide to alveolar macrophages: Comparative study revealing differences in their mechanism of toxic action

 

作者: I. M. C. M. Rietjens,   M. C. M. Poelen,   R. A. Hempenius,   M. J. J. Gijbels,   G. M. Alink,  

 

期刊: Journal of Toxicology and Environmental Health  (Taylor Available online 1986)
卷期: Volume 19, issue 4  

页码: 555-568

 

ISSN:0098-4108

 

年代: 1986

 

DOI:10.1080/15287398609530952

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

The toxicity of ozone and nitrogen dioxide is generally ascribed to their oxidative potential. In this study their toxic mechanism of action was compared using an intact cell model. Rat alveolar macrophages were exposed by means of gas diffusion through a Teflon film. In this in vitro system, ozone appeared to be 10 times more toxic than nitrogen dioxide.

 

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