Toxicity of ozone and nitrogen dioxide to alveolar macrophages: Comparative study revealing differences in their mechanism of toxic action
作者:
I. M. C. M. Rietjens,
M. C. M. Poelen,
R. A. Hempenius,
M. J. J. Gijbels,
G. M. Alink,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1986)
卷期:
Volume 19,
issue 4
页码: 555-568
ISSN:0098-4108
年代: 1986
DOI:10.1080/15287398609530952
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The toxicity of ozone and nitrogen dioxide is generally ascribed to their oxidative potential. In this study their toxic mechanism of action was compared using an intact cell model. Rat alveolar macrophages were exposed by means of gas diffusion through a Teflon film. In this in vitro system, ozone appeared to be 10 times more toxic than nitrogen dioxide.
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