Chirality of quartz. Fibrosis and tumour development in dust inoculated mice
作者:
P,
期刊:
European Journal of Cancer Prevention
(OVID Available online 1991)
卷期:
Volume 1,
issue 1
页码: 39-42
ISSN:0959-8278
年代: 1991
出版商: OVID
关键词: Carcinogenesis;Chirality;quartz.
数据来源: OVID
摘要:
Dextro (d) and laevo (l) forms of quartz dust was inoculated intranasally and subcutaneously into 2-month-old (C57 x BALB/c)F1 mice which were killed 18 months later. Both d and l quartz caused fibrosis, liver nodule formation and an enhanced incidence of lymphoma leukemia. However, the tumour incidence was significantly higher in l than in d quartz dust-treated animals. It is concluded that in addition to effects clearly independent of chirality there is evidence that the biological response to nonidentical mirror images of solid crystals may differ.
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