Effects of Corticosterone on Hippocampal Slice Electrophysiology in Normal and Adrenalectomized BALB/c Mice
作者:
Marc Rey,
Edmond Carlier,
Bernard Soumireu-Mourat,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 46,
issue 5
页码: 424-429
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124856
出版商: S. Karger AG
关键词: Corticosterone;Adrenalectomy;Hippocampus;Mouse;Slice
数据来源: Karger
摘要:
Modulation of CA1 electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of corticosterone (CT) was studied in hippocampal slice preparations from normal (sham) and adrenalectomized (ADX) BALB/c mice. In the sham group, CT effects on the population spike (PS) amplitude were biphasic: at a low dose (200 pM) CT induced a delayed increase; at a moderate dose (2,000 pM), a rapid and partially reversible decrease was observed, and at higher doses (5,000 and 10,000 pM) this decrease was more pronounced after 30 min of washout. Diminution of latency and paired-pulse facilitation were obtained for the CT concentration inducing an increase of the PS amplitude. In the ADX group, similar CT effects were observed for lower doses: a decrease of the PS amplitude was observed for 40 and 100 pM and an increase for 5 pM, but variations of the PS amplitude were weaker than in the sham group. The role of the different CT receptor systems in this neuromodulatory effect is discussed.
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