Prediction of Steady-State Nortriptyline Plasma Levels by the Repeated One-Point Method
作者:
William K. Fant,
Wolfgang A. Ritschel,
Sri K. Alwis,
Sandra Roe,
Jerry Ehret,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1984)
卷期:
Volume 9,
issue 5
页码: 450-456
ISSN:0312-5963
年代: 1984
出版商: ADIS
数据来源: ADIS
摘要:
10 psychiatric inpatients with a diagnosis of depression were entered into a prospective study to investigate the repeated one-point method as a method of predicting steady-state concentrations for nortriptyline. Four males and 4 females completed all requirements of the protocol.Single plasma concentrations obtained after the first and second daily doses were found to be accurate predictors of the steady-state minimum plasma concentrations. The difference between the measured and the predicted steady-state minimum values ranged from 2.10 to 32.7 &mgr;g/L with a standard deviation 10.4 and a mean of 10.5 &mgr;g/L, assuming a normal distribution. The correlation coefficient of predictedversusmeasured concentrations was 0.946 with 90% confidence limits, ranging from 0.800 to 0.990.The repeated one-point method was found to be an accurate predictor of steady-state minimum plasma concentrations in patients receiving nortriptyline. This method should allow for individual adjustment of dose while minimising the time required to achieve therapeutic, non-toxic plasma concentrations.
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