Mechanistic studies on diamine oxidase: oxidation of α,ω-diamines does not involve an enamine intermediate
作者:
Stephen S. Gavin,
Angela M. Equi,
David J. Robins,
期刊:
Canadian Journal of Chemistry
(NRC Available online 1994)
卷期:
Volume 72,
issue 1
页码: 31-34
ISSN:0008-4042
年代: 1994
DOI:10.1139/v94-006
出版商: NRC Research Press
数据来源: NRC
摘要:
Three β,β,β′,β′-2H4-labelled α,ω-diamines were synthesized and incubated with pea seedling diamine oxidase. The aminoaldehydes formed by oxidative deamination cyclized to the corresponding imines, which were trapped with benzoylacetic acid. In all three cases the acetophenone derivatives produced were shown by NMR and mass spectrometry to contain four deuterium atoms. The retention of all four deuterium atoms demonstrates that oxidative deamination of α,ω-diamines catalyzed by pea seedling diamine oxidase does not involve an enamine intermediate as previously suggested.
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