Prognostic value of direct spread in Dukes' C cases of rectal cancer
作者:
Jeremy Jass,
M. Path,
Sharon Love,
期刊:
Diseases of the Colon & Rectum
(OVID Available online 1989)
卷期:
Volume 32,
issue 6
页码: 477-480
ISSN:0012-3706
年代: 1989
出版商: OVID
关键词: Rectal cancer;Prognosis;Spread;Multivariate analysis
数据来源: OVID
摘要:
&NA;Seventy‐six cancers with involved lymph nodes but with limitation of direct spread in continuity to the bowel wall (Astler‐Coller C1cases) were matched with Astler‐Coller C2cases for clinical variables, macroscopic appearance of tumor, grade of differentiation, and number of positive lymph nodes. Despite this stringent matching, spread was shown to be an important prognostic variable in univariate survival analysis. Estimated five‐year survival for Astler‐Coller C1cases was just below 80 percent, equivalent to B2(Dukes' B) cases. When spread was analyzed in the presence of additional prognostic variables (character of invasive margin and lymphocytic infiltration) by multivariate modeling, its independent prognostic status was maintained. Improved survival for C1cases was not explained by a lower incidence of local pelvic recurrence. Mechanisms to account for the better, prognosis are proposed. This study reaffirms the importance of multivariate techniques of analysis in the assessment of prognosis of patients with rectal cancer
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