In experiments in dogs the ventilatory and circulatory conditions prevailing with the ventilatory pattern in high‐frequency positive‐pressure ventilation (HFPPV) were investigated with use of a pneumatic valve principle and a ventilator system of an “open” character. Keeping the gas input constant the importance of insufflation frequency and insufflation time and the reactions to various levels of positive end‐expiratory pressure (PEEP) were investigated in terms of changes in arterial pH, Pco2and Po2.With the volumes of delivered gas kept constant, an increasing insufflation frequency from 60 to 100 per min gave a parallel decrease in tidal volume accompanied by lower maximum intratracheal pressures and a significant decrease in alveolar ventilation. Also taking into account the possibilities of inducing a suppression of the spontaneous respiration, higher ventilatory frequencies than 60 per min do not seem to introduce any further advantages.Including the associated effects on cardiac output and venous admixture, the cardiopulmonary and circulatory parameters studied did not show any substantial changes with PEEP levels below 7.5–10 cm H2O. Thus the level of PEEP, which often is part of the ventilatory pattern in HFPPV, does not seem to have any untoward influence on the circulation (stroke volume, cardiac output, total peripheral vascular resistance) and oxygen transport (arterial oxygen content and oxygen flux) in normovo