Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false‐positive serological test for syphilis
作者:
J. B. Weinberg,
S. J. Hasstedt,
M. H. Skolnick,
W. J. Kimberling,
B. Baty,
期刊:
American Journal of Medical Genetics
(WILEY Available online 1980)
卷期:
Volume 5,
issue 1
页码: 57-67
ISSN:0148-7299
年代: 1980
DOI:10.1002/ajmg.1320050108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: elliptocytosis;lipomatosis;BFPSTS;pedigree;likelihood;dominant;systemic lupus erythematosus;linkage
数据来源: WILEY
摘要:
AbstractElliptocytosis, multiple lipomatosis, and biological false‐positive serological test for syphilis (BFPSTS) were found in a single individual. One hundred eighty relatives were tested for the three diseases: 74 were typed for seven blood group antigens, and 58 were typed for four electrophoretic enzyme markers. Likelihood analysis of the pedigree data confirmed independent dominant inheritance for elliptocytosis and lipomatosis. BFPSTS appears dominant, but the analysis was inconclusive. No linkages were found between any disease gene and any marker gene. Two female pedigree members with BFPSTS developed systemic lupus erythematosus, a finding in agreement with the previously described association. The analysis did not lead to any conclusions about the causal relationship between the two trait
点击下载:
PDF
(594KB)
返 回