Influence of sodium hyaluronate on the meiotic effect of pilocarpine in rabbits
作者:
CamberOla,
EdmanPeter,
GurnyRobert,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 6
页码: 779-784
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709034844
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Sodium hyaluronate is a potential vehicle for drugs given topically to the eye. In the present study, the effect of sodium hyaluronate on the miosis induced by pilocarpine in rabbits was investigated. Addition of 0.2 and 0.75% sodium hyaluronate to 1% pilocarpine hydrochloride in buffer resulted in an increased effect measured as area under the miosis-time curve (AUC) and duration of miosis. A comparison between a commercially available 1% pilocarpine preparation and the preparations containing sodium hyaluronate showed that sodium hyaluronate improves the effect parameters. No adverse effects with sodium hyaluronate were observed. Possible mechanisms inducing these improvements are discussed.
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