Platelet Adhesion and Platelet Thrombus Formation on Subendothelium of Human Arteries and Veins Exposed to Flowing Bloodin vitro. A Comparison with Rabbit Aorta
作者:
T.B. Tschopp,
H.R. Baumgartner,
K. Silberbauer,
H. Sinzinger,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 1
页码: 19-29
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214287
出版商: S. Karger AG
关键词: Platelet adhesion;Platelet aggregation;Subendothelium;Platelet-vessel wall interaction;Blood flow
数据来源: Karger
摘要:
Subendothelium of blood vessel segments from elderly patients was exposed in a perfusion chamber to citrated blood under arterial blood flow conditions. The resulting platelet adhesion and thrombus formation was assessed morphometrically. The results show that the time course and the extent of platelet adhesion and aggregation were similar to the results obtained previously with subendothelium from rabbit arteries. The extent of surface-induced platelet aggregation was furthermore governed by both the properties of the exposed surface as well as those of the blood perfusate. No significant differences with regard to platelet reactivity were found between veins and arteries and the extent of surface-induced platelet aggregation was rather low.
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