Rapidly Progressive (‘Crescentic’) Glomerulonephritis and Monoclonal Gammapathies
作者:
Alain Meyrier,
Pierre Simon,
Françoise Mignon,
Liliane Striker,
Marie-Paule Ramée,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 38,
issue 3
页码: 156-162
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183299
出版商: S. Karger AG
关键词: Monoclonal gammapathy;Plasma cell dyscrasia;Waldenström;Rapidly progressive glomerulonephritis;Glomerular crescents
数据来源: Karger
摘要:
In 3 patients rapidly progressive glomerulonephritis revealed plasma cell dyscrasia in 2 cases and Waldenstrom’s macroglobulinemia in the 3rd. Renal biopsy showed proliferative glomerulonephritis with marked endo- and extracapillary (crescentic) proliferation. In case 1, corticosteroids and cyclophosphamide favorably influenced the course of the disease. The 2nd patient was not treated and went on to maintenance hemodialysis. In the 3rd case, plasma exchange and cytotoxic drugs allowed discontinuation of hemodialysis. Thirteen other cases of proliferative glomerulonephritis associated with monoclonal gammapathies have been described in the literature, including 3 with crescents. B-cell dyscrasia should be considered a possible etiology in a patient with crescentic glomerulonephritis. In such case we show that treatment of the hematologic disorder can be followed by a dramatic improvement of renal functio
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