Hepatitis B virus DNA in serum from patients with acute hepatitis B
作者:
Kim Krogsgaard,
Peter Kryger,
Jan Aldershvile,
Poul Andersson,
Christian Brechot,
期刊:
Hepatology
(WILEY Available online 1985)
卷期:
Volume 5,
issue 1
页码: 10-13
ISSN:0270-9139
年代: 1985
DOI:10.1002/hep.1840050104
出版商: W.B. Saunders
数据来源: WILEY
摘要:
AbstractSera from 77 consecutive patients with acute type B hepatitis were examined for hepatitis B virus DNA (HBV DNA) by a spot hybridization method. The median follow‐up time was 8 months (range, 1 week to 3 years). HBV DNA was detected in 26 (34%) patients on admission to the hospital. A significant positive correlation was found between short duration of symptoms and the presence of HBV DNA (p<0.025). Twenty‐four (46%) of 52 HBeAg‐positive patients were HBV DNA positive compared to 2 HBV DNA‐positive patients of 25 HBeAg‐negative patients (8%) (p<0.001). Four HBeAg‐negative patients had serum HBV DNA initially or during follow‐up; three had anti‐HBe. Six of 77 patients with acute type B hepatitis (8%) became chronic HBsAg carriers, and HBV DNA was detectable from 5 months to more than 3 years after onset of symptoms. The presence of serum HBV DNA for more than 8 weeks after initial symptoms may predict development of a chronic HBsAg carrier state. In none of the chronic carriers was serum HBV DNA present after cl
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